PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) are both autologous blood products used in regenerative medicine and dentistry. While they are similar in some ways, they have distinct differences in preparation, composition, and clinical application.
What it is:
A concentration of platelets in plasma derived from the patient’s own blood.
Preparation:
Blood is drawn and mixed with an anticoagulant to prevent clotting.
Centrifuged to separate the layers (RBCs, platelet-poor plasma, and platelet-rich plasma).
Often activated with calcium chloride or thrombin before application.
Composition:
High concentration of platelets (3–5 times baseline).
Growth factors (PDGF, TGF-β, VEGF, etc.) to stimulate healing.
Low fibrin content (liquid consistency).
Uses:
Orthopedics (e.g., tendon injuries, arthritis)
Dermatology (e.g., hair restoration, skin rejuvenation)
Dentistry (e.g., bone grafting, implantology)
Sports medicine
What it is:
A fibrin matrix rich in platelets and leukocytes, also derived from the patient’s blood.
Preparation:
Blood is drawn without anticoagulant.
Centrifuged at a lower speed and shorter time than PRP.
Clot forms naturally due to lack of anticoagulant, creating a fibrin matrix.
Composition:
Platelets + leukocytes
A dense fibrin network that traps growth factors for slow release
Natural, no chemical additives
Uses:
Oral and maxillofacial surgery
Bone regeneration and sinus lifts
Periodontal therapy
Wound healing
| Feature | PRP | PRF |
|---|---|---|
| Anticoagulant used | Yes | No |
| Form | Liquid | Gel-like fibrin matrix |
| Growth factor release | Rapid (short-term) | Slow, sustained (7–10 days) |
| Leukocyte content | Low or absent | High |
| Application | Injected or topically applied | Placed as membrane or plug |
